Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons.
Identifieur interne : 001F31 ( Main/Exploration ); précédent : 001F30; suivant : 001F32Gait is associated with an increase in tonic firing of the sub-cuneiform nucleus neurons.
Auteurs : B. Piallat [France] ; S. Chabardès ; N. Torres ; V. Fraix ; L. Goetz ; E. Seigneuret ; E. Bardinet ; M. Ferraye ; B. Debu ; P. Krack ; J. Yelnik ; P. Pollak ; A L BenabidSource :
- Neuroscience [ 0306-4522 ] ; 2009.
English descriptors
- KwdEn :
- Action Potentials (physiology), Electrodes, Implanted, Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (pathology), Humans, Imaging, Three-Dimensional (methods), Locomotion (physiology), Neurons (physiology), Parkinson Disease (complications), Parkinson Disease (surgery), Stereotaxic Techniques, Tegmentum Mesencephali (pathology), Wakefulness.
- MESH :
- complications : Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- methods : Imaging, Three-Dimensional.
- pathology : Gait Disorders, Neurologic, Tegmentum Mesencephali.
- physiology : Action Potentials, Locomotion, Neurons.
- surgery : Parkinson Disease.
- Electrodes, Implanted, Humans, Stereotaxic Techniques, Wakefulness.
Abstract
In animals, the pedunculopontine (PPN) and the sub-cuneiform (SCU) nuclei located in the upper brainstem are involved during the processing of gait. Similar functional nuclei are suspected in humans but their role in gait is unclear. Here we show that, using extra-cellular recordings of the PPN/SCU region obtained in two parkinsonian patients, the SCU neurons increased their firing rate without modifying their firing pattern during mimicked steps. We conclude that SCU neurons are activated during gait processes.
DOI: 10.1016/j.neuroscience.2008.10.046
PubMed: 19063948
Affiliations:
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Le document en format XML
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Pollak</name></author><author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name></author></analytic><series><title level="j">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (physiology)</term><term>Electrodes, Implanted</term><term>Gait Disorders, Neurologic (etiology)</term><term>Gait Disorders, Neurologic (pathology)</term><term>Humans</term><term>Imaging, Three-Dimensional (methods)</term><term>Locomotion (physiology)</term><term>Neurons (physiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (surgery)</term><term>Stereotaxic Techniques</term><term>Tegmentum Mesencephali (pathology)</term><term>Wakefulness</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Imaging, Three-Dimensional</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Tegmentum Mesencephali</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Action Potentials</term><term>Locomotion</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Electrodes, Implanted</term><term>Humans</term><term>Stereotaxic Techniques</term><term>Wakefulness</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In animals, the pedunculopontine (PPN) and the sub-cuneiform (SCU) nuclei located in the upper brainstem are involved during the processing of gait. 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Ferraye</name><name sortKey="Fraix, V" sort="Fraix, V" uniqKey="Fraix V" first="V" last="Fraix">V. Fraix</name><name sortKey="Goetz, L" sort="Goetz, L" uniqKey="Goetz L" first="L" last="Goetz">L. Goetz</name><name sortKey="Krack, P" sort="Krack, P" uniqKey="Krack P" first="P" last="Krack">P. Krack</name><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name><name sortKey="Seigneuret, E" sort="Seigneuret, E" uniqKey="Seigneuret E" first="E" last="Seigneuret">E. Seigneuret</name><name sortKey="Torres, N" sort="Torres, N" uniqKey="Torres N" first="N" last="Torres">N. Torres</name><name sortKey="Yelnik, J" sort="Yelnik, J" uniqKey="Yelnik J" first="J" last="Yelnik">J. Yelnik</name></noCountry><country name="France"><noRegion><name sortKey="Piallat, B" sort="Piallat, B" uniqKey="Piallat B" first="B" last="Piallat">B. Piallat</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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